common causes of anaphylaxis

Many things can cause or “trigger” life-threatening allergic reactions (anaphylaxis), including food, medicines, stinging and biting insects (bugs), allergy (immunotherapy) injections, exercise, or unknown causes3,4:

  • Foods, such as peanuts, tree nuts, fish, shellfish, milk, eggs, sesame, and food additives3
  • Insect stings often associated with bees, hornets, wasps, and ants, as well as bites from insects such as flies, mosquitoes, ticks, and caterpillars3,5
  • Medicines, such as penicillin, aspirin, and nonsteroidal anti-inflammatory drugs (NSAIDs)1
  • Rubber latex, such as that found in latex gloves and some medical and dental equipment1,3
  • Exercise, including exercise associated with factors that include aspirin, NSAIDs, or food ingestion before or after exercise.1 (NOTE: Patients with exercise-induced anaphylaxis should carry epinephrine and a "medical alert" identification of their condition.1)

This information is not a substitute for professional medical advice, diagnosis or treatment. You are strongly encouraged to seek the advice of your doctor or other medical professional with any questions regarding your medical condition.

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  • Epinephrine auto-injector is an emergency injection ("shot") of epinephrine. It is a medicine used for life-threatening allergic reactions such as severe swelling, breathing problems, or loss of blood pressure. Allergic reactions can be caused by stinging and biting insects (bugs), allergy injections, food, medicines, exercise, or unknown causes.
  • After using epinephrine auto-injector go to your doctor or emergency room right away for more medical treatment.

Important Safety Information

  • Make sure to tell your doctor about all your medical conditions and allergies, but especially if you:
    • have heart disease or high blood pressure
    • have diabetes
    • have thyroid conditions
    • have asthma
    • have depression or other mental disease
    • have Parkinson's disease
    • are pregnant
    • are allergic to any of the ingredients in epinephrine auto-injector
  • Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins and herbal supplements. Some medicines may cause serious side effects if taken while you use epinephrine auto-injector. Some medicines may affect how epinephrine auto-injector works, or epinephrine auto-injector may affect how your other medicines work. Diabetic patients may need to adjust the dose of their diabetes medicines or insulin after using epinephrine auto-injector.
  • Avoid injecting epinephrine auto-injector into your buttock or any other part of your body, other than the middle of the outer side of your thigh (upper leg). Avoid injecting epinephrine auto-injector into a vein.
  • Too much epinephrine (epinephrine auto-injector) can cause dangerously high blood pressure, stroke, or death. If you take certain medicines, you may develop serious life-threatening side effects from the epinephrine in epinephrine auto-injector. Be sure to tell your doctor about all the medicines you take, especially medicines for asthma.
  • Patients with certain medical conditions, or who take certain medicines, may get more side effects from epinephrine auto-injector, or the side effects may last longer. This includes patients who take certain types of medicines for asthma, allergies, depression, hyperthyroidism, high blood pressure, and heart disease. Patients with heart disease may feel chest pain (angina). Patients with mental disease or Parkinson's disease may have worsening symptoms of their illness. Epinephrine auto-injector (epinephrine) can cause the following reactions. Some reactions can be serious. They usually go away with rest.
    • faster, irregular (wrong) or "pounding" heartbeat
    • throbbing headache
    • paleness
    • feelings of over excitement, anxiety, or fear
    • weakness or shakiness
    • dizziness
    • nausea and vomiting
    • sweating
  • These are not all the possible side effects of epinephrine auto-injector. For more information, ask your doctor or pharmacist.
  • You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.
  • After use/disposal
    • The remaining liquid that is left after this fixed dose cannot be further administered and should be discarded.
    • Put the auto-injector, needle first, into the carrying case.
    • Put the light gray case top over the non-needle end of the epinephrine auto-injector unit and close the case.
    • Give your used epinephrine auto-injector to a healthcare worker for disposal. Do NOT throw away in a regular trash can.

Click here for full Prescribing Information for epinephrine injection, USP auto-injector.

For more information about epinephrine injection, USP auto-injector, ask your doctor or call 1-888-894-6528. Ask your doctor if epinephrine injection, USP auto-injector is right for you.

You are encouraged to report negative side effects of prescription drugs to the FDA. Go to or call 1-800-FDA-1088.